Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.

The herpes simplex virus DNA polymerase consists of two subunits--a catalytic subunit and an accessory subunit, UL42, that increases processivity. Mutations affecting the extreme C terminus of the catalytic subunit specifically disrupt subunit interactions and ablate virus replication, suggesting th...

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Detalhes bibliográficos
Main Authors: Digard, P, Williams, K P, Hensley, P, Brooks, I S, Dahl, C E, Coen, D M
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC42538/
https://ncbi.nlm.nih.gov/pubmed/7878000
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