Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.

The herpes simplex virus DNA polymerase consists of two subunits--a catalytic subunit and an accessory subunit, UL42, that increases processivity. Mutations affecting the extreme C terminus of the catalytic subunit specifically disrupt subunit interactions and ablate virus replication, suggesting th...

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Hlavní autoři: Digard, P, Williams, K P, Hensley, P, Brooks, I S, Dahl, C E, Coen, D M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC42538/
https://ncbi.nlm.nih.gov/pubmed/7878000
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