Specific inhibition of herpes simplex virus DNA polymerase by helical peptides corresponding to the subunit interface.

The herpes simplex virus DNA polymerase consists of two subunits--a catalytic subunit and an accessory subunit, UL42, that increases processivity. Mutations affecting the extreme C terminus of the catalytic subunit specifically disrupt subunit interactions and ablate virus replication, suggesting th...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Digard, P, Williams, K P, Hensley, P, Brooks, I S, Dahl, C E, Coen, D M
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42538/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7878000/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.5.1456
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