Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions

In the present study, we assessed, if the novel dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 radiosensitizes triple negative (TN) MDA-MB-231 and estrogen receptor (ER) positive MCF-7 cells to ionizing radiation under various oxygen conditions, s...

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Detaylı Bibliyografya
Asıl Yazarlar: Kuger, Sebastian, Cörek, Emre, Polat, Bülent, Kämmerer, Ulrike, Flentje, Michael, Djuzenova, Cholpon S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Libertas Academica 2014
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964191/
https://ncbi.nlm.nih.gov/pubmed/24678241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BCBCR.S13693
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