Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer

The transcription factor E-twenty-six related gene (ERG), which is overexpressed through gene fusion with the androgen-responsive gene transmembrane protease, serine 2 (TMPRSS2) in ∼40% of prostate tumors, is a key driver of prostate carcinogenesis. Ablation of ERG would disrupt a key oncogenic tran...

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Detalles Bibliográficos
Autores principales: Wang, Shan, Kollipara, Rahul K., Srivastava, Nishi, Li, Rui, Ravindranathan, Preethi, Hernandez, Elizabeth, Freeman, Eva, Humphries, Caroline G., Kapur, Payal, Lotan, Yair, Fazli, Ladan, Gleave, Martin E., Plymate, Stephen R., Raj, Ganesh V., Hsieh, Jer-Tsong, Kittler, Ralf
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964108/
https://ncbi.nlm.nih.gov/pubmed/24591637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322198111
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