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Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer
The transcription factor E-twenty-six related gene (ERG), which is overexpressed through gene fusion with the androgen-responsive gene transmembrane protease, serine 2 (TMPRSS2) in ∼40% of prostate tumors, is a key driver of prostate carcinogenesis. Ablation of ERG would disrupt a key oncogenic tran...
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| Auteurs principaux: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3964108/ https://ncbi.nlm.nih.gov/pubmed/24591637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322198111 |
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