Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer

The transcription factor E-twenty-six related gene (ERG), which is overexpressed through gene fusion with the androgen-responsive gene transmembrane protease, serine 2 (TMPRSS2) in ∼40% of prostate tumors, is a key driver of prostate carcinogenesis. Ablation of ERG would disrupt a key oncogenic tran...

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Detalhes bibliográficos
Main Authors: Wang, Shan, Kollipara, Rahul K., Srivastava, Nishi, Li, Rui, Ravindranathan, Preethi, Hernandez, Elizabeth, Freeman, Eva, Humphries, Caroline G., Kapur, Payal, Lotan, Yair, Fazli, Ladan, Gleave, Martin E., Plymate, Stephen R., Raj, Ganesh V., Hsieh, Jer-Tsong, Kittler, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964108/
https://ncbi.nlm.nih.gov/pubmed/24591637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322198111
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