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The 2.1 Å Resolution Structure of Cyanopindolol-Bound β(1)-Adrenoceptor Identifies an Intramembrane Na(+) Ion that Stabilises the Ligand-Free Receptor
The β(1)-adrenoceptor (β(1)AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. We have determined the structure of an ultra-thermostable β(1)AR mutant bound to the weak partial agonist cyanopindolol to 2.1 Å resolution. High-quality c...
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| Main Authors: | , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Public Library of Science
2014
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3963952/ https://ncbi.nlm.nih.gov/pubmed/24663151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092727 |
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