The 2.1 Å Resolution Structure of Cyanopindolol-Bound β(1)-Adrenoceptor Identifies an Intramembrane Na(+) Ion that Stabilises the Ligand-Free Receptor

The β(1)-adrenoceptor (β(1)AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. We have determined the structure of an ultra-thermostable β(1)AR mutant bound to the weak partial agonist cyanopindolol to 2.1 Å resolution. High-quality c...

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Hauptverfasser: Miller-Gallacher, Jennifer L., Nehmé, Rony, Warne, Tony, Edwards, Patricia C., Schertler, Gebhard F. X., Leslie, Andrew G. W., Tate, Christopher G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963952/
https://ncbi.nlm.nih.gov/pubmed/24663151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092727
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