Monocrotophos Induces the Expression and Activity of Xenobiotic Metabolizing Enzymes in Pre-Sensitized Cultured Human Brain Cells

The expression and metabolic profile of cytochrome P450s (CYPs) is largely missing in human brain due to non-availability of brain tissue. We attempted to address the issue by using human brain neuronal (SH-SY5Y) and glial (U373-MG) cells. The expression and activity of CYP1A1, 2B6 and 2E1 were carr...

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Bibliographic Details
Main Authors: Tripathi, Vinay K., Kumar, Vivek, Singh, Abhishek K., Kashyap, Mahendra P., Jahan, Sadaf, Pandey, Ankita, Alam, Sarfaraz, Khan, Feroz, Khanna, Vinay K., Yadav, Sanjay, Lohani, Mohtshim, Pant, Aditya B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963866/
https://ncbi.nlm.nih.gov/pubmed/24663500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091946
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