Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity

We demonstrate the role of molecular switching of TrkA/p75(NTR) signaling cascade in organophosphate pesticide-Monocrotophos (MCP) induced neurotoxicity in stem cell derived cholinergic neurons and in rat brain. Our in-silico studies reveal that MCP followed the similar pattern of binding as stauros...

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Pubblicato in:Sci Rep
Autori principali: Kumar, Vivek, Gupta, Amit Kumar, Shukla, Rajendra Kumar, Tripathi, Vinay Kumar, Jahan, Sadaf, Pandey, Ankita, Srivastava, Akriti, Agrawal, Megha, Yadav, Sanjay, Khanna, Vinay Kumar, Pant, Aditya Bhushan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570211/
https://ncbi.nlm.nih.gov/pubmed/26370177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14038
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