Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75(NTR) Activity Is Neurotoxic through a Paracrine Mechanism

In normal adult retinas, NGF receptor TrkA is expressed in retinal ganglion cells (RGC), whereas glia express p75(NTR). During retinal injury, endogenous NGF, TrkA, and p75(NTR) are up-regulated. Paradoxically, neither endogenous NGF nor exogenous administration of wild type NGF can protect degenera...

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Bibliografiske detaljer
Main Authors: Bai, Yujing, Dergham, Pauline, Nedev, Hinyu, Xu, Jing, Galan, Alba, Rivera, Jose Carlos, ZhiHua, Shi, Mehta, Hrishikesh M., Woo, Sang B., Sarunic, Marinko V., Neet, Kenneth E., Saragovi, H. Uri
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998128/
https://ncbi.nlm.nih.gov/pubmed/20943663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147801
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