Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase Activity()

Glioblastoma contains a hierarchy of stem-like cancer cells, but how this hierarchy is established is unclear. Here, we show that asymmetric Numb localization specifies glioblastoma stem-like cell (GSC) fate in a manner that does not require Notch inhibition. Numb is asymmetrically localized to CD13...

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Bibliografiske detaljer
Main Authors: Jiang, Xiuli, Xing, Hongyan, Kim, Tae-Min, Jung, Yuchae, Huang, Wei, Yang, Hong Wei, Song, Shengye, Park, Peter J., Carroll, Rona S., Johnson, Mark D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963835/
https://ncbi.nlm.nih.gov/pubmed/22553175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1120
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