Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; however, while these compounds have potent antimalarial activity, they suffer from poor aqueous solubility and metabolic instability. Here, further structure–activity relationship studies are described that...

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Main Authors: Murugesan, Dinakaran, Kaiser, Marcel, White, Karen L, Norval, Suzanne, Riley, Jennifer, Wyatt, Paul G, Charman, Susan A, Read, Kevin D, Yeates, Clive, Gilbert, Ian H
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963473/
https://ncbi.nlm.nih.gov/pubmed/23918316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300177
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