Synthesis and Biological Evaluation of Coumarin Replacements of Novobiocin as Hsp90 Inhibitors

[Image: see text] Since Hsp90 modulates all six hallmarks of cancer simultaneously, it has become an attractive target for the development of cancer chemotherapeutics. In an effort to develop more efficacious compounds for Hsp90 inhibition, novobiocin analogues were prepared by replacing the central...

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Main Authors: Kusuma, Bhaskar Reddy, Khandelwal, Anuj, Gu, Wen, Brown, Douglas, Liu, Weiya, Vielhauer, George, Holzbeierlein, Jeffrey, Blagg, Brian S. J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963410/
https://ncbi.nlm.nih.gov/pubmed/24461493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.12.056
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