Class I and II Histone Deacetylase Inhibition by ITF2357 Reduces SLE Pathogenesis In Vivo

We sought to determine if a specific class I and II HDAC inhibitor (ITF2357) was able to decrease disease in lupus-prone NZB/W mice through regulation of T cell profiles. From 22 - 38 weeks-of-age, NZB/W and non-lupus NZW mice were treated with ITF2357 (5 mg/kg or 10 mg/kg), or vehicle control. Body...

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Main Authors: Regna, Nicole L., Chafin, Cristen B., Hammond, Sarah E., Puthiyaveetil, Abdul G., Caudell, David L., Reilly, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963170/
https://ncbi.nlm.nih.gov/pubmed/24503172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2014.01.002
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