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A Functional Interaction between Hippo-YAP Signaling and FoxO1 Mediates the Oxidative Stress Response
The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis that negatively regulates cell growth and survival. Here we report that YAP, the terminal effector of the Hippo pathway, interacts with FoxO1 in the nucleus of cardiomyocytes, thereby promoting survival. YAP a...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3962829/ https://ncbi.nlm.nih.gov/pubmed/24525530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4315 |
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