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Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP
The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionarily conserved 14-3-3-binding site whose p...
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| Izdano u: | Genes Dev |
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| Glavni autori: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4495399/ https://ncbi.nlm.nih.gov/pubmed/26109051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.264234.115 |
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