Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionarily conserved 14-3-3-binding site whose p...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Chen, Qian, Zhang, Nailing, Xie, Rui, Wang, Wei, Cai, Jing, Choi, Kyung-Suk, David, Karen Kate, Huang, Bo, Yabuta, Norikazu, Nojima, Hiroshi, Anders, Robert A., Pan, Duojia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4495399/
https://ncbi.nlm.nih.gov/pubmed/26109051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.264234.115
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