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Integrated Population Pharmacokinetic/Viral Dynamic Modeling of Lopinavir/Ritonavir in HIV-1 Treatment Naïve Patients
BACKGROUND: Lopinavir (LPV)/ritonavir (RTV) co-formulation (LPV/RTV) is a widely used protease inhibitor (PI) based regimen to treat HIV-infection. As with all PIs, the trough concentration (C(trough)) is a primary determinant of response, but the optimum exposure remains poorly defined. The primary...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3962720/ https://ncbi.nlm.nih.gov/pubmed/24311282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-013-0122-1 |
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