Interleukin-18 mediates interleukin-1-induced cardiac dysfunction

Patients with heart failure (HF) have enhanced systemic IL-1 activity, and, in the experimental mouse model, IL-1 induces left ventricular (LV) systolic dysfunction. Whether the effects of IL-1 are direct or mediated by an inducible cytokine, such as IL-18, is unknown. Recombinant human IL-18-bindin...

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Autori principali: Toldo, Stefano, Mezzaroma, Eleonora, O'Brien, Laura, Marchetti, Carlo, Seropian, Ignacio M., Voelkel, Norbert F., Van Tassell, Benjamin W., Dinarello, Charles A., Abbate, Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
Soggetti:
Signaling and Stress Response
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962640/
https://ncbi.nlm.nih.gov/pubmed/24531812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00795.2013
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