Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease

Maternal diet can affect fetal gene expression through epigenetic mechanisms. Wilson disease (WD), which is caused by autosomal recessive mutations in ATP7B encoding a biliary copper transporter, is characterized by excessive hepatic copper accumulation, but variability in disease severity. We teste...

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Main Authors: Medici, Valentina, Shibata, Noreene M, Kharbanda, Kusum K, Islam, Mohammad S, Keen, Carl L, Kim, Kyoungmi, Tillman, Brittany, French, Samuel W, Halsted, Charles H, LaSalle, Janine M
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962539/
https://ncbi.nlm.nih.gov/pubmed/24220304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.27110
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