Wilson disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease

Hepatic methionine metabolism may play an essential role in regulating methylation status and liver injury in Wilson disease (WD) through the inhibition of S-adenosylhomocysteine hydrolase (SAHH) by copper (Cu) and the consequent accumulation of S-adenosylhomocysteine (SAH). We studied the transcrip...

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Hauptverfasser: Medici, Valentina, Shibata, Noreene M., Kharbanda, Kusum K., LaSalle, Janine M., Woods, Rima, Liu, Sarah, Engelberg, Jesse A., Devaraj, Sridevi, Török, Natalie J., Jiang, Joy X., Havel, Peter J., Lönnerdal, Bo, Kim, Kyoungmi, Halsted, Charles H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566330/
https://ncbi.nlm.nih.gov/pubmed/22945834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26047
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