Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model

Wilson disease (WD), a genetic disorder affecting copper transport, is characterized by hepatic and neurological manifestations with variable and often unpredictable presentation. Global DNA methylation in liver was previously modified by dietary choline in tx-j mice, a spontaneous mutant model of W...

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Sparad:
Bibliografiska uppgifter
I publikationen:Epigenetics
Huvudupphovsmän: Medici, Valentina, Kieffer, Dorothy A., Shibata, Noreene M., Chima, Harpreet, Kim, Kyoungmi, Canovas, Angela, Medrano, Juan F., Islas-Trejo, Alma D., Kharbanda, Kusum K., Olson, Kristin, Su, Ruijun J., Islam, Mohammad S., Syed, Raisa, Keen, Carl L., Miller, Amy Y., Rutledge, John C., Halsted, Charles H., LaSalle, Janine M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221658/
https://ncbi.nlm.nih.gov/pubmed/27611852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2016.1231289
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