Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model

Wilson disease (WD), a genetic disorder affecting copper transport, is characterized by hepatic and neurological manifestations with variable and often unpredictable presentation. Global DNA methylation in liver was previously modified by dietary choline in tx-j mice, a spontaneous mutant model of W...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Medici, Valentina, Kieffer, Dorothy A., Shibata, Noreene M., Chima, Harpreet, Kim, Kyoungmi, Canovas, Angela, Medrano, Juan F., Islas-Trejo, Alma D., Kharbanda, Kusum K., Olson, Kristin, Su, Ruijun J., Islam, Mohammad S., Syed, Raisa, Keen, Carl L., Miller, Amy Y., Rutledge, John C., Halsted, Charles H., LaSalle, Janine M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221658/
https://ncbi.nlm.nih.gov/pubmed/27611852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2016.1231289
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