Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease

Wilson disease (WD) is caused by mutations in the copper transporter ATP7B, leading to copper accumulation in the liver and brain. Excess copper inhibits S-adenosyl-L-homocysteine hydrolase, leading to variable WD phenotypes from widespread alterations in DNA methylation and gene expression. Previou...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Mordaunt, Charles E, Shibata, Noreene M, Kieffer, Dorothy A, Członkowska, Anna, Litwin, Tomasz, Weiss, Karl Heinz, Gotthardt, Daniel N, Olson, Kristin, Wei, Dongguang, Cooper, Stewart, Wan, Yu-Jui Yvonne, Ali, Mohamed R, LaSalle, Janine M, Medici, Valentina
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
General Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216211/
https://ncbi.nlm.nih.gov/pubmed/30010856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy262
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