Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease

Wilson disease (WD) is caused by mutations in the copper transporter ATP7B, leading to copper accumulation in the liver and brain. Excess copper inhibits S-adenosyl-L-homocysteine hydrolase, leading to variable WD phenotypes from widespread alterations in DNA methylation and gene expression. Previou...

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Pubblicato in:Hum Mol Genet
Autori principali: Mordaunt, Charles E, Shibata, Noreene M, Kieffer, Dorothy A, Członkowska, Anna, Litwin, Tomasz, Weiss, Karl Heinz, Gotthardt, Daniel N, Olson, Kristin, Wei, Dongguang, Cooper, Stewart, Wan, Yu-Jui Yvonne, Ali, Mohamed R, LaSalle, Janine M, Medici, Valentina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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General Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216211/
https://ncbi.nlm.nih.gov/pubmed/30010856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy262
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