Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery

The past decade has witnessed a paradigm shift in preclinical drug discovery with structure-based drug design (SBDD) making a comeback while high-throughput screening (HTS) methods have continued to generate disappointing results. There is a deficit of information between identified hits and the man...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lounnas, Valère, Ritschel, Tina, Kelder, Jan, McGuire, Ross, Bywater, Robert P., Foloppe, Nicolas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Research Network of Computational and Structural Biotechnology (RNCSB) Organization 2013
Schlagworte:
Mini Reviews
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962124/
https://ncbi.nlm.nih.gov/pubmed/24688704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5936/csbj.201302011
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