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Emerging Computational Methods for the Rational Discovery of Allosteric Drugs
[Image: see text] Allosteric drug development holds promise for delivering medicines that are more selective and less toxic than those that target orthosteric sites. To date, the discovery of allosteric binding sites and lead compounds has been mostly serendipitous, achieved through high-throughput...
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| Опубликовано в: : | Chem Rev |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Chemical Society
2016
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| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4901368/ https://ncbi.nlm.nih.gov/pubmed/27074285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.5b00631 |
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