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Emerging Computational Methods for the Rational Discovery of Allosteric Drugs

[Image: see text] Allosteric drug development holds promise for delivering medicines that are more selective and less toxic than those that target orthosteric sites. To date, the discovery of allosteric binding sites and lead compounds has been mostly serendipitous, achieved through high-throughput...

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Dades bibliogràfiques
Publicat a:Chem Rev
Autors principals: Wagner, Jeffrey R., Lee, Christopher T., Durrant, Jacob D., Malmstrom, Robert D., Feher, Victoria A., Amaro, Rommie E.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901368/
https://ncbi.nlm.nih.gov/pubmed/27074285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrev.5b00631
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