Structure and Permeability of Ion-channels by Integrated AFM and Waveguide TIRF Microscopy

Membrane ion channels regulate key cellular functions and their activity is dependent on their 3D structure. Atomic force microscopy (AFM) images 3D structure of membrane channels placed on a solid substrate. Solid substrate prevents molecular transport through ion channels thus hindering any direct...

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Hauptverfasser: Ramachandran, Srinivasan, Arce, Fernando Teran, Patel, Nirav R., Quist, Arjan P., Cohen, Daniel A., Lal, Ratnesh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961736/
https://ncbi.nlm.nih.gov/pubmed/24651823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04424
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