NO(•) Binds Human Cystathionine β-Synthase Quickly and Tightly

The hexa-coordinate heme in the H(2)S-generating human enzyme cystathionine β-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO(•) or CO at the reduced iron. Despite the proposed physiological relevance of this inhibitory mechanism, unlike CO, NO(•) was...

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Bibliografische gegevens
Hoofdauteurs: Vicente, João B., Colaço, Henrique G., Mendes, Marisa I. S., Sarti, Paolo, Leandro, Paula, Giuffrè, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
Onderwerpen:
Molecular Biophysics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961681/
https://ncbi.nlm.nih.gov/pubmed/24515102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507533
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