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Dynamics of Carbon Monoxide Binding to Cystathionine β-Synthase
Cystathionine β-synthase (CBS), condenses homocysteine, a toxic metabolite, with serine, in a pyridoxal phosphate-dependent reaction. It also contains a heme cofactor, to which CO or NO can bind, resulting in enzyme inhibition. To understand the mechanism of this regulation, we have investigated the...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745537/ https://ncbi.nlm.nih.gov/pubmed/16505479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M600246200 |
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