Dynamics of Carbon Monoxide Binding to Cystathionine β-Synthase

Cystathionine β-synthase (CBS), condenses homocysteine, a toxic metabolite, with serine, in a pyridoxal phosphate-dependent reaction. It also contains a heme cofactor, to which CO or NO can bind, resulting in enzyme inhibition. To understand the mechanism of this regulation, we have investigated the...

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Main Authors: Puranik, Mrinalini, Weeks, Colin L., Lahaye, Dorothee, Kabil, Ömer, Taoka, Shinichi, Nielsen, Steen Brøndsted, Groves, John T., Banerjee, Ruma, Spiro, Thomas G.
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745537/
https://ncbi.nlm.nih.gov/pubmed/16505479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M600246200
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