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A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?

The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5′-phosphate- (PLP-) dependent cystathionine β-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Vicente, João B., Colaço, Henrique G., Malagrinò, Francesca, Santo, Paulo E., Gutierres, André, Bandeiras, Tiago M., Leandro, Paula, Brito, José A., Giuffrè, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381205/
https://ncbi.nlm.nih.gov/pubmed/28421128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8940321
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