Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods

Biosynthesis of hydrogen sulfide (H(2)S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MST). Several lines of evidence have shown a close correla...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zuhra, Karim, Sousa, Pedro M. F., Paulini, Giulia, Lemos, Ana Rita, Kalme, Zenta, Bisenieks, Imants, Bisenieks, Egils, Vigante, Brigita, Duburs, Gunars, Bandeiras, Tiago M., Saso, Luciano, Giuffrè, Alessandro, Vicente, João B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346012/
https://ncbi.nlm.nih.gov/pubmed/30679627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36994-w
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