Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes

Casitas B-lineage lymphoma-b (Cbl-b) is a ubiquitin ligase (E3) that modulates signaling by tagging molecules for degradation. It is a complex protein with multiple domains and binding partners that are not involved in ubiquitinating substrates. Herein, we demonstrate that Cbl-b, but not c-Cbl, is r...

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Detalhes bibliográficos
Main Authors: Veselits, Margaret, Tanaka, Azusa, Lipkowitz, Stanley, O'Neill, Shannon, Sciammas, Roger, Finnegan, Alison, Zhang, Jian, Clark, Marcus R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961229/
https://ncbi.nlm.nih.gov/pubmed/24651487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089792
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