Igβ ubiquitination activates PI3K signals required for endosomal sorting

A wealth of in vitro data has demonstrated a central role for receptor ubiquitination in endocytic sorting. However, how receptor ubiquitination functions in vivo is poorly understood. Herein, we report that ablation of B cell antigen receptor ubiquitination in vivo uncouples the receptor from CD19...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Veselits, Margaret, Tanaka, Azusa, Chen, Yaoqing, Hamel, Keith, Mandal, Malay, Kandasamy, Matheswaran, Manicassamy, Balaji, O’Neill, Shannon K., Wilson, Patrick, Sciammas, Roger, Clark, Marcus R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716028/
https://ncbi.nlm.nih.gov/pubmed/29141870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161868
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