Differences in CD1d protein structure determine species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant natural killer T (iNKT)Cells

Isoglobotrihexosylceramide (iGb3) has been identified as a potent CD1d-presented self-antigen for mouse iNKT cells. The role of iGb3 in humans remains unresolved, however, as there have been conflicting reports about iGb3-dependent human iNKT-cell activation, and humans lack iGb3 synthase, a key enz...

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Main Authors: Sanderson, Joseph P., Brennan, Patrick J., Mansour, Salah, Matulis, Gediminas, Patel, Onisha, Lissin, Nikolai, Godfrey, Dale I., Kawahara, Kazuyoshi, Zähringer, Ulrich, Rossjohn, Jamie, Brenner, Michael B., Gadola, Stephan D.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961145/
https://ncbi.nlm.nih.gov/pubmed/23280365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242952
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