Humans Lack iGb3 Due to the Absence of Functional iGb3-Synthase: Implications for NKT Cell Development and Transplantation

The glycosphingolipid isoglobotrihexosylceramide, or isogloboside 3 (iGb3), is believed to be critical for natural killer T (NKT) cell development and self-recognition in mice and humans. Furthermore, iGb3 may represent an important obstacle in xenotransplantation, in which this lipid represents the...

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Detalhes bibliográficos
Main Authors: Christiansen, Dale, Milland, Julie, Mouhtouris, Effie, Vaughan, Hilary, Pellicci, Daniel G, McConville, Malcolm J, Godfrey, Dale I, Sandrin, Mauro S
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2459210/
https://ncbi.nlm.nih.gov/pubmed/18630988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060172
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