Innate-Like Control of Human iNKT Cell Autoreactivity via the Hypervariable CDR3β Loop

Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule CD1d. The structure of human iNKT TCRs is uni...

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Main Authors: Matulis, Gediminas, Sanderson, Joseph P., Lissin, Nikolai M., Asparuhova, Maria B., Bommineni, Gopal R., Schümperli, Daniel, Schmidt, Richard R., Villiger, Peter M., Jakobsen, Bent K., Gadola, Stephan D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889927/
https://ncbi.nlm.nih.gov/pubmed/20585371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000402
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