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Molecular Simulations Illuminate the Role of Regulatory Components of the RNA Polymerase from the Hepatitis C Virus in Influencing Protein Structure and Dynamics

[Image: see text] The RNA polymerase (gene product NS5B) from the hepatitis C virus is responsible for replication of the viral genome and is a validated drug target for new therapeutic agents. NS5B has a structure resembling an open right hand (containing the fingers, palm, and thumb subdomains), a...

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Sonraí Bibleagrafaíochta
Main Authors: Davis, Brittny C., Thorpe, Ian F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961064/
https://ncbi.nlm.nih.gov/pubmed/23738897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400251g
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