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Lysosome and Calcium Dysregulation in Alzheimer’s Disease – Partners in Crime
Early onset familial Alzheimer’s disease (FAD) is caused by mutations of Presenilin 1, Presenilin 2, and amyloid precursor protein. Beyond the effects of PS1 mutations on proteolytic functions of the gamma-secretase complex, mutant or deficient PS1 disrupts lysosomal function and calcium homeostasis...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3960943/ https://ncbi.nlm.nih.gov/pubmed/24256243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20130201 |
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