Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis

Tumor suppressor p53 is frequently mutated in tumors. Mutant p53 (Mutp53) proteins often gain new activities in promoting tumorigenesis, defined as gain-of-function (GOF). Mutp53 often accumulates at high levels in tumors, which promotes mutp53 GOF in tumorigenesis. The mechanism of mutp53 accumulat...

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Bibliographic Details
Main Authors: Zheng, Tongsen, Wang, Jiabei, Zhao, Yuhan, Zhang, Cen, Lin, Meihua, Wang, Xiaowen, Yu, Haiyang, Liu, Lianxin, Feng, Zhaohui, Hu, Wenwei
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960723/
https://ncbi.nlm.nih.gov/pubmed/24356649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3996
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