Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease

BACKGROUND: Prostate cancer (PrCa) is one of the most common diseases to affect men worldwide and among the leading causes of cancer-related death. The purpose of this study was to use second-generation sequencing technology to assess the frequency of deleterious mutations in 22 tumour suppressor ge...

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Detalhes bibliográficos
Main Authors: Leongamornlert, D, Saunders, E, Dadaev, T, Tymrakiewicz, M, Goh, C, Jugurnauth-Little, S, Kozarewa, I, Fenwick, K, Assiotis, I, Barrowdale, D, Govindasami, K, Guy, M, Sawyer, E, Wilkinson, R, Antoniou, A C, Eeles, R, Kote-Jarai, Z
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960610/
https://ncbi.nlm.nih.gov/pubmed/24556621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.30
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