Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease

BACKGROUND: Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes. METHODS: We sequenced germline whole exomes from 139 ag...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Mijuskovic, Martina, Saunders, Edward J., Leongamornlert, Daniel A., Wakerell, Sarah, Whitmore, Ian, Dadaev, Tokhir, Cieza-Borrella, Clara, Govindasami, Koveela, Brook, Mark N., Haiman, Christopher A., Conti, David V., Eeles, Rosalind A., Kote-Jarai, Zsofia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035259/
https://ncbi.nlm.nih.gov/pubmed/29915322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0141-7
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