Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel

BACKGROUND: Rare germline mutations in DNA repair genes are associated with prostate cancer (PCa) predisposition and prognosis. OBJECTIVE: To quantify the frequency of germline DNA repair gene mutations in UK PCa cases and controls, in order to more comprehensively evaluate the contribution of indiv...

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Publicat a:Eur Urol
Autors principals: Leongamornlert, Daniel A., Saunders, Edward J., Wakerell, Sarah, Whitmore, Ian, Dadaev, Tokhir, Cieza-Borrella, Clara, Benafif, Sarah, Brook, Mark N., Donovan, Jenny L., Hamdy, Freddie C., Neal, David E., Muir, Kenneth, Govindasami, Koveela, Conti, David V., Kote-Jarai, Zsofia, Eeles, Rosalind A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695475/
https://ncbi.nlm.nih.gov/pubmed/30777372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eururo.2019.01.050
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