BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients

BACKGROUND: A family history of prostate cancer (PrCa) is a strong risk factor for the disease, indicating that inherited factors are important in this disease. We previously estimated that about 2% of PrCa cases diagnosed ⩽55 years harbour a BRCA2 mutation and PrCa among BRCA2 carriers has been sho...

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Detalhes bibliográficos
Main Authors: Kote-Jarai, Z, Leongamornlert, D, Saunders, E, Tymrakiewicz, M, Castro, E, Mahmud, N, Guy, M, Edwards, S, O'Brien, L, Sawyer, E, Hall, A, Wilkinson, R, Dadaev, T, Goh, C, Easton, D, Goldgar, D, Eeles, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208504/
https://ncbi.nlm.nih.gov/pubmed/21952622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.383
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