Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer

Poly (ADP-ribose) polymerase 1 (PARP1) plays a critical role in ovarian cancer progression. However, the epigenetic mechanism regulating PARP1 transcription remains largely unknown. Here, we show that the hypomethylated ETS1 motif is a key regulatory element for the PARP1 gene in BRCA1-mutated ovari...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Li, Da, Bi, Fang-Fang, Cao, Ji-Min, Cao, Chen, Li, Chun-Yan, Liu, Bo, Yang, Qing
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2013
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960209/
https://ncbi.nlm.nih.gov/pubmed/24448423
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