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Copper-catalyzed asymmetric conjugate reduction as a route to novel β-azaheterocyclic acid derivatives

A chiral copper-hydride catalyst for the asymmetric conjugate reduction of α,β-unsaturated carbonyl compounds has been used for the reduction of substrates containing β-nitrogen substituents. A new set of reaction conditions has allowed for a variety of β-azaheterocyclic acid derivatives to be synth...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Rainka, Matthew P., Aye, Yimon, Buchwald, Stephen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395992/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15067136/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307764101
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