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Highly enantioselective epoxidation of styrenes: Implication of an electronic effect on the competition between spiro and planar transition states

Asymmetric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been investigated. High enantioselectivity (89–93% enantiomeric excess) has been attained for this challenging class of alkenes. Mechanistic studies show that substituents on the ketone catalyst can ha...

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Detalhes bibliográficos
Main Authors: Hickey, Matthew, Goeddel, David, Crane, Zackary, Shi, Yian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC395987/
https://ncbi.nlm.nih.gov/pubmed/15069190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307548101
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