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Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
A process is reported for efficient, enantioselective production of key intermediates for the common chiral side chain of statin-type cholesterol-lowering drugs such as Lipitor (atorvastatin) and Crestor (rosuvastatin). The process features a one-pot tandem aldol reaction catalyzed by a deoxyribose-...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC395986/ https://ncbi.nlm.nih.gov/pubmed/15069189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307563101 |
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