Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates

A process is reported for efficient, enantioselective production of key intermediates for the common chiral side chain of statin-type cholesterol-lowering drugs such as Lipitor (atorvastatin) and Crestor (rosuvastatin). The process features a one-pot tandem aldol reaction catalyzed by a deoxyribose-...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Greenberg, William A., Varvak, Alexander, Hanson, Sarah R., Wong, Kelvin, Huang, Hongjun, Chen, Pei, Burk, Mark J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Asymmetric Catalysis Special Feature Part II
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395986/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15069189/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307563101
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