Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state

A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through int...

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Hlavní autoři: Santagata, Sandro, Mendillo, Marc L., Tang, Yun-chi, Subramanian, Aravind, Perley, Casey C., Roche, Stéphane P., Wong, Bang, Narayan, Rajiv, Kwon, Hyoungtae, Koeva, Martina, Amon, Angelika, Golub, Todd R., Porco, John A., Whitesell, Luke, Lindquist, Susan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959726/
https://ncbi.nlm.nih.gov/pubmed/23869022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1238303
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