HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...

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Detalhes bibliográficos
Main Authors: Mendillo, Marc L., Santagata, Sandro, Koeva, Martina, Bell, George W., Hu, Rong, Tamimi, Rulla M., Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438889/
https://ncbi.nlm.nih.gov/pubmed/22863008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.031
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